DoD Lupus, Impact Award

Description

The LRP Impact Award encourages applications that supportthe full spectrum of research projects or ideas that specifically focus onscientific and clinical lupus issues, which, if successfully addressed, havethe potential to make a major impact in lupus research. Applications should include awell-formulated, testable hypothesis based on strong scientific rationale thatis established through inferential reasoning and/or critical review andanalysis of the literature. Inclusionof preliminary data is encouraged. Thefollowing are important aspects of the Impact Award: · Impact: The proposed research, ifsuccessful, should impact an area of paramount importance in lupus disease. It is the responsibility of the PI to clearlyand explicitly describe the potential impact(s) of the proposed study forindividuals living with lupus and to convey its level of significance. TheImpact Award supports high-risk, high-reward studies that have the potential tomake a significant advancement in lupus research. · ResearchStrategy: Thescientific rationale and experimental methodology should demonstrate criticalunderstanding and in-depth analysis of lupus. Experimental strategies may be novel or may be based on strong rationalederived from a literature review. · ResearchTeam: The research team’sbackground should be appropriate with respect to its ability to successfullycomplete the proposed work. · FocusAreas: Theproposed research must address at leastone of the FY19 LRP Focus Areas. Clinicaltrials are not allowed under this Program Announcement. The proposed research must be relevant to active dutyService members, Veterans, military beneficiaries, and/or the American public. The anticipated total costs budgeted for the entire periodof performance for an FY19 LRP Impact Award will not exceed $525,000. Refer to Section II.D.5,Funding Restrictions, for detailed fundinginformation. TheCDMRP expects to allot approximately $3.15M to fund approximately six Impact Awardapplications. Funding of applicationsreceived is contingent upon the availability of Federal funds for this programas well as the number of applications received, the quality and merit of theapplications as evaluated by scientific and programmatic review, and therequirements of the Government. Funds tobe obligated on any award resulting from this funding opportunity will beavailable for use for a limited time period based on the fiscal year of thefunds. It is anticipated that awardsmade from this FY19 funding opportunity will be funded with FY19 funds, whichwill expire for use on September 30, 2025. Awards will be made no later than September 30, 2020. For additional information, refer to Section II.F.1,Federal Award Notices. The types of awards made under the Program Announcement willbe assistance agreements (grants or cooperative agreements). The level of involvement on the part of theDepartment of Defense (DoD) during project performance is the key factor indetermining whether to award a grant or cooperative agreement. An assistance agreement (grant or cooperative agreement) isappropriate when the Federal Government transfers a “thing of value” to a“state, local government,” or “other recipient” to carry out a public purposeof support or stimulation authorized by a law of the United States, instead ofacquiring property or service for the direct benefit and use of the U.S.Government. An assistance agreement cantake the form of a grant or cooperative agreement. If “no substantial involvement” on the partof the funding agency is anticipated, a grant award will be made (31 USC6304). Conversely, if substantialinvolvement on the part of the funding agency is anticipated, a cooperativeagreement will be made (31 USC 6305) and the award will identify the specificsubstantial involvement. Substantialinvolvement may include collaboration, participation, or intervention in theresearch to be performed under the award. The award type, along with the start date, will be determined during thenegotiation process.

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