Closed · RFA-DA-23-003 · CFDA 93.279 · Discretionary

Investigating Transposable Elements and Mobile DNA as Targets of Integration for Establishing HIV Reservoirs in the Brain (R61/R33 - Clinical Trial Optional)

Federal grant opportunity posted by National Institutes of Health, cataloged on Grants.gov.

Varies
Award range
Closed
Status
August 3, 2022
Close date
-
Expected awards

The verdict

Investigating Transposable Elements and Mobile DNA as Targets of Integration for Establishing HIV Reservoirs in the Brain (R61/R33 - Clinical Trial Optional) is a closed discretionary listing from National Institutes of Health that offered Varies by applicant. Future funding cycles may be published under the same CFDA number. PlainGrants indexes 12,419 other opportunities from National Institutes of Health.

Varies
award range
Closed
application status
93.279
CFDA program
12,419
other opportunities from National Institutes of Health

Archived opportunity record

Investigating Transposable Elements and Mobil… is closed (last close August 3, 2022). The parent program page for CFDA 93.279 is the reliable place to catch re-announcements. National Institutes of Health still indexes 12,419 other opportunities here.

According to Grants.gov (extract vintage 2026-08-10), this record reflects the officially published listing. See methodology.

Deadline tracker

Application window closed

Closed August 3, 2022

Posted Feb 11 Closes Aug 3

Instrument

Grant

Description

oMany substances of abuse, including cocaine, methamphetamine, and several opioids exert powerful environmental insults on genomic DNA in the brain that induce expression of transposable elements and other mobile DNA. Transposable elements and mobile DNA, which comprise almost 50% of the human genome, are typically silenced through strong epigenetic modifications. When transposable elements and mobile DNA become active in people who use drugs of abuse, they potentially provide multiple integration sites for HIV in microglia. HIV integration into these unstable regions could lead to major chromosomal rearrangements and global dysregulation of transcription, ultimately contributing to HIV-associated Neurocognitive Disorder (HAND) and providing a mechanism by which drugs of abuse increase the probability of reactivating microglial HIV reservoirs. Understanding the factors that influence HIV integration in these microglial reservoirs is crucial to developing next-generation HIV therapies and potential cures. This concept addresses these gaps by fostering studies aimed at providing a deeper understanding of the complex interplay among HIV, substances of abuse, inflammation, and disease progression.

Wide-open applicant board · 15 Grants.gov doors

Investigating Transposable Elements and Mobil… prints 15 distinct Grants.gov eligibility doors (State governments; County governments; City or township governments; Special district governments; +11 more). Filter fit before reading award size as demand — most applicant classes appear on the row. The extract does not mark applicant cost-sharing as required. Instrument: Grant. Funding-activity codes span Education · Health (ED;HL). This eligibility-code string dominates the National Institutes of Health book (9,741 peers, 78% of 12,420).

Code 00
State governments
Code 01
County governments
Code 02
City or township governments
Code 04
Special district governments
Code 05
Independent school districts
Code 06
Public / state-controlled institutions of higher education
Code 07
Federally recognized tribal governments
Code 08
Public / Indian housing authorities
Code 11
Native American tribal organizations (other than Federally recognized tribal governments)
Code 12
Nonprofits with 501(c)(3) status (other than IHEs)
Code 13
Nonprofits without 501(c)(3) status (other than IHEs)
Code 20
Private institutions of higher education
Code 22
For-profit organizations other than small businesses
Code 23
Small businesses
Code 25
Others (see official listing text)

Codes are Grants.gov eligibility category values from the extract vintage 2026-08-10. Confirm the full eligibility statement on the official listing or the Grants.gov eligibility reference.

Official Listing on Grants.gov

View full details, application forms, and submission instructions.

View on Grants.gov

Agency Contact

NIH OER Webmaster OERWebmaster03@od.nih.gov

What to do next

Investigating Transposable Elements and Mobil… is closed; use the parent program and agency catalog for the next funding cycle.

  • Parent CFDA 93.279 may publish future NOFOs under the same assistance listing. Open program
  • Drug Abuse Research Programs indexes 170 Grants.gov listings in this extract. Program profile
  • National Institutes of Health lists 12,419 other indexed opportunities on PlainGrants. Agency catalog

Opportunity deadlines and eligibility change on Grants.gov; PlainGrants mirrors the extract and is not the submission system.

Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.

Data sourced from the SAM.gov Assistance Listings and Grants.gov. See our methodology for details. Retrieved and formatted by PlainGrants