Closed · HT9425-23-ALSRP-TDA · CFDA 12.420 · Discretionary
DOD Amyotrophic Lateral Sclerosis, Therapeutic Development Award
Federal grant opportunity posted by Defense Health Agency Contracting Activity - DHACA, cataloged on Grants.gov.
- Varies
- Award range
- Closed
- Status
- July 13, 2023
- Close date
- 4
- Expected awards
The verdict
DOD Amyotrophic Lateral Sclerosis, Therapeutic Development Award is a closed discretionary listing from Defense Health Agency Contracting Activity - DHACA that offered Varies by applicant across 4 expected awards. Future funding cycles may be published under the same CFDA number. PlainGrants indexes 1,795 other opportunities from Defense Health Agency Contracting Activity - DHACA.
- Varies
- award range
- Closed
- application status
- 4
- expected awards
- 12.420
- CFDA program
Archived opportunity record
DOD Amyotrophic Lateral Sclerosis is closed (last close July 13, 2023). Check the agency catalog for replacement NOFOs. Defense Health Agency Contracting Activity - DHACA still indexes 1,795 other opportunities here.
According to Grants.gov (extract vintage 2026-08-10), this record reflects the officially published listing. See methodology.
Deadline tracker
Application window closed
Closed July 13, 2023
Est. Total Funding
$9,600,000
Expected Awards
4
Instrument
Grant
Description
The FY23 ALSRP Therapeutic Development Award supports research ranging from preclinical validation of therapeutic leads through U.S. Food and Drug Administration (FDA) Investigational New Drug (IND)-enabling studies. The proposed studies are expected to be empirical in nature and product driven. Applicants with limited ALS experience are strongly encouraged to include collaborators with substantial experience in the relevant ALS model systems, endpoints, and pathophysiology. Examples of activities that will be supported by this award include:Confirmation of candidate therapeutics obtained from screening or by other means, including optimization of potency and pharmacological properties and testing of derivatives and sister compounds.Validation of pilot efficacy studies (such as from an ALSRP Therapeutic Idea Award), including the use of additional ALS model systems and/or replicating preliminary data with more time points or additional doses.IND-enabling studies to include: compound characterization; absorption, distribution, metabolism, and excretion (ADME) studies; studies on formulation and stability leading to Good Manufacturing Practice production methods; dose/response and toxicology studies in relevant model systems.Applications supported by this award must begin with lead compounds in hand and must include preliminary data relevant to the phase of development, such as:Proof of identity and puritySelectivity for the intended target over closely related targetsAvailability of primary and secondary in vitro bioactivity assays for optimization or structure–activity relationship studiesAvailability of clear efficacy data in at least one relevant preclinical Amyotrophic Lateral Sclerosis (ALS) model, with adequate power and methods.Applicants seeking support for basic research focused on ALS drug discovery are encouraged to apply for the FY23 ALSRP Therapeutic Idea Award (Funding Opportunity Number HT9425-23-ALSRP-TIA), which does not require preliminary data (https://cdmrp.health.mil/funding/alsrp).
Catch-all / unrestricted eligibility mark · HT9425-23-ALSRP-TDA
Grants.gov marks DOD Amyotrophic Lateral Sclerosis with a catch-all / unrestricted eligibility code (Unrestricted / see official listing). Read the official announcement text for the real applicant filter — the code alone is not a door list. The extract does not mark applicant cost-sharing as required. Instrument: Grant. Funding-activity code maps to Science and Technology / R&D (ST). This eligibility-code string dominates the Defense Health Agency Contracting Activity - DHACA book (1,791 peers, 100% of 1,796).
- Code 99
- Unrestricted / see official listing
Codes are Grants.gov eligibility category values from the extract vintage 2026-08-10. Confirm the full eligibility statement on the official listing or the Grants.gov eligibility reference.
Official Listing on Grants.gov
View full details, application forms, and submission instructions.
Agency Contact
CDMRP Help Desk Phone: 301-682-5507 Email: help@eBRAP.org
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What to do next
DOD Amyotrophic Lateral Sclerosis is closed; use the parent program and agency catalog for the next funding cycle.
- Browse open federal opportunities in the same category when this listing is closed. Open opportunities
- Look up CFDA 12.420 across all indexed listings before you commit to this opportunity alone. Eligibility finder
- Compare award ranges across federal categories before you pick a single CFDA. All categories
Opportunity deadlines and eligibility change on Grants.gov; PlainGrants mirrors the extract and is not the submission system.
Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.
Read our methodology - how this data is sourced, computed, and verified.
| Publisher | PlainGrants |
| Sources | the SAM.gov Assistance Listings and Grants.gov |