Closed · HR001124S0032 · CFDA 12.910 · Discretionary

Broad-Spectrum Antagonists For Editors (B-SAFE)

Federal grant opportunity posted by DARPA - Biological Technologies Office, cataloged on Grants.gov.

Varies
Award range
Closed
Status
August 12, 2024
Close date
-
Expected awards

The verdict

Broad-Spectrum Antagonists For Editors (B-SAFE) is a closed discretionary listing from DARPA - Biological Technologies Office that offered Varies by applicant. Future funding cycles may be published under the same CFDA number. PlainGrants indexes 73 other opportunities from DARPA - Biological Technologies Office.

Varies
award range
Closed
application status
12.910
CFDA program
73
other opportunities from DARPA - Biological Technologies Office

Archived opportunity record

Broad-Spectrum Antagonists For Editors is closed (last close August 12, 2024). Check the agency catalog for replacement NOFOs. DARPA - Biological Technologies Office still indexes 73 other opportunities here.

According to Grants.gov (extract vintage 2026-08-10), this record reflects the officially published listing. See methodology.

Deadline tracker

Application window closed

Closed August 12, 2024

Posted Jun 14 Closes Aug 12

Instrument

Procurement Contract

Description

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to identify and optimize novel molecules that exhibit inhibitory effects on Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated proteins (CRISPR-Cas) gene editing processes. The Broad-Spectrum Antagonists for Editors (B-SAFE) program is explicitly seeking transformative approaches enabling the discovery or design of novel inhibitors of gene editing technologies with enhanced activity, utility, and breadth of coverage. Novel inhibitor activity will be assessed in vitro over the course of the program and a subset of top performing molecules will be selected for scale-up at quantities sufficient for testing and evaluation by Department of Defense (DoD) stakeholders. In concert, DARPA is interested in exploring methods to rapidly discover inhibitor molecules for novel gene editing technologies beyond CRISPR-Cas systems to keep pace with the rapidly advancing field and promote the safe, controlled use of these technologies. Research that generates incremental improvements to the existing state-of-the-art are specifically excluded.

Catch-all / unrestricted eligibility mark · HR001124S0032

Grants.gov marks Broad-Spectrum Antagonists For Editors with a catch-all / unrestricted eligibility code (Others (see official listing text)). Read the official announcement text for the real applicant filter — the code alone is not a door list. The extract does not mark applicant cost-sharing as required. Instrument: Procurement Contract. Funding-activity code maps to Science and Technology / R&D (ST). This eligibility-code string dominates the DARPA - Biological Technologies Office book (44 peers, 59% of 74).

Code 25
Others (see official listing text)

Codes are Grants.gov eligibility category values from the extract vintage 2026-08-10. Confirm the full eligibility statement on the official listing or the Grants.gov eligibility reference.

Official Listing on Grants.gov

View full details, application forms, and submission instructions.

View on Grants.gov

Agency Contact

BAA Coordinator BSAFE@darpa.mil

More from DARPA - Biological Technologies Office

Closed Closed September 30, 2026

Biological Technologies

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What to do next

Broad-Spectrum Antagonists For Editors is closed; use the parent program and agency catalog for the next funding cycle.

  • Browse open federal opportunities in the same category when this listing is closed. Open opportunities
  • Look up CFDA 12.910 across all indexed listings before you commit to this opportunity alone. Eligibility finder
  • Compare award ranges across federal categories before you pick a single CFDA. All categories

Opportunity deadlines and eligibility change on Grants.gov; PlainGrants mirrors the extract and is not the submission system.

Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.

Read our methodology - how this data is sourced, computed, and verified.

Data sourced from the SAM.gov Assistance Listings and Grants.gov. See our methodology for details. Retrieved and formatted by PlainGrants