Closed · NNJ25ZSA001N · CFDA 43.007 · Discretionary
2025 Human Exploration Research Opportunities (HERO) NOFO
Federal grant opportunity posted by NASA Johnson Space Center, cataloged on Grants.gov.
- Varies
- Award range
- Closed
- Status
- October 31, 2025
- Close date
- -
- Expected awards
The verdict
2025 Human Exploration Research Opportunities (HERO) NOFO is a closed discretionary listing from NASA Johnson Space Center that offered Varies by applicant. Future funding cycles may be published under the same CFDA number. PlainGrants indexes 64 other opportunities from NASA Johnson Space Center.
- Varies
- award range
- Closed
- application status
- 43.007
- CFDA program
- 64
- other opportunities from NASA Johnson Space Center
Recently closed NOFO
This listing closed on October 31, 2025. Watch CFDA 43.007 (Space Science Research) for the next funding cycle. Historical award band was Varies by applicant.
According to Grants.gov (extract vintage 2026-08-10), this record reflects the officially published listing. See methodology.
Deadline tracker
Application window closed
Closed October 31, 2025
Instrument
Procurement Contract
Description
NASA Human Exploration Research Opportunities (HERO) Released Notice of Funding Opportunity (NOFO), entitled, “Human Exploration Research Opportunities (HERO)” (NNJ25ZSA001N) , has been released. This NOFO will solicit applied research in support of NASA’s Human Research Program (HRP). This NOFO is available through the the NASA Solicitation and Proposal Integrated Review and Evaluation System (NSPIRES) at: https://tinyurl.com/HERO25NOFO. The research will fall into one or more categories corresponding to HRP’s five Elements: Space Radiation, Human Health Countermeasures, Exploration Medical Capability, Human Factors and Behavioral Performance, and Research Operations and Integration. This NOFO covers all aspects of research to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. Awards generally range from under $250K per year for focused, limited efforts (e.g., data analysis) to $1.2M per year for extensive activities (e.g., development of scientific hardware) and will be made as grants. The funds available for awards in each research opportunity offered in this NOFO range from less than one million to several million dollars. This range allows selection from a few to as many as a dozen proposals depending on the program objectives and the submission of proposals of merit. The period of performance for an award can range from one to five years. [g1] Any changes or modifications to any of these guidelines will be specified in the descriptions of the relevant research opportunities in the appendices of this solicitation. Details of the topics will be given in the appendices of the NOFO. Unless otherwise specified, appendices will use a two-step solicitation process requiring that a compliant and relevant Step-1 proposal be submitted in order to be considered to be invited to submit a Step-2 proposal. Proposal due dates will be staggered throughout the HERO open period of November 1, 2024 to October 2025. The first proposal due date (for Step-1 proposals submitted in response to Appendix A) is December 2, 2024. The electronic submission is required by the due date for proposal submission. Proposal due dates are given in the appendices, which will be posted at https://nspires.nasaprs.com. Interested proposers should monitor https://nspires.nasaprs.com or register and subscribe to the Space Operations Mission Directorate (SOMD) electronic notifications system through the NSPIRES account subscription services. New program elements or amendments to this NOFO through October 2025 will be posted in NSPIRES, after which time release of a subsequent HERO NOFO is planned. All categories of United States (U.S.) institutions are eligible to submit proposals in response to the NOFO. Principal Investigators may collaborate with universities, Federal Government laboratories, the private sector, and state and local government laboratories. In all such arrangements, the applying entity is expected to be responsible for administering the project according to the management approach presented in the proposal. NASA’s policy is to conduct research with non-U.S. organizations on a cooperative, no exchange-of-funds basis. Thank you for your continued interest in NASA. Please refer to the solicitation document for contact information.
Catch-all / unrestricted eligibility mark · NNJ25ZSA001N
Grants.gov marks 2025 Human Exploration Research Opportunities with a catch-all / unrestricted eligibility code (Unrestricted / see official listing). Read the official announcement text for the real applicant filter — the code alone is not a door list. The extract does not mark applicant cost-sharing as required. Instrument: Procurement Contract. Funding-activity code maps to Science and Technology / R&D (ST). This eligibility-code string dominates the NASA Johnson Space Center book (58 peers, 89% of 65).
- Code 99
- Unrestricted / see official listing
Codes are Grants.gov eligibility category values from the extract vintage 2026-08-10. Confirm the full eligibility statement on the official listing or the Grants.gov eligibility reference.
Official Listing on Grants.gov
View full details, application forms, and submission instructions.
Parent Grant Program
Space Science Research
National Aeronautics and Space Administration
Agency Contact
Steven Platts, Ph.D. Chief Scientist, Human Research Program NASA Johnson Space Center (Mail Code SA2) Houston, TX 77058
More from NASA Johnson Space Center
HERO Appendix E: Space Radiobiology and Human Health Countermeasures Topics
GROUND BASED STUDIES IN RADIOBIOLOGY 2013
COOPERATIVE AGREEMENT NOTICE FOR NASA INTERNSHIPS
RESEARCH AND TECHNOLOGY DEVELOPMENT TO SUPPORT CREW HEALTH AND PERFORMANCE IN SPACE EXPLORATION MISSIONS
RESEARCH AND TECHNOLOGY DEVELOPMENT TO SUPPORT CREW HEALTH AND PERFORMANCE IN SPACE EXPLORATION MISSIONS
What to do next
2025 Human Exploration Research Opportunities is closed; use the parent program and agency catalog for the next funding cycle.
- Parent CFDA 43.007 may publish future NOFOs under the same assistance listing. Open program
- Space Science Research indexes 1 Grants.gov listings in this extract. Program profile
- NASA Johnson Space Center lists 64 other indexed opportunities on PlainGrants. Agency catalog
Opportunity deadlines and eligibility change on Grants.gov; PlainGrants mirrors the extract and is not the submission system.
Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.
Read our methodology - how this data is sourced, computed, and verified.
| Publisher | PlainGrants |
| Sources | the SAM.gov Assistance Listings and Grants.gov |