Open · RFA-NS-27-007 · CFDA 93.213;93.233;93.273;93.279;93.395;93.837;93.838;93.839;93.840;93.846;93.853;93.865;93.866;93.867 · Discretionary

HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)

Federal grant opportunity posted by National Institutes of Health, cataloged on Grants.gov.

Varies
Award range
Open
Status
850d
Days left
3
Expected awards

The verdict

HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) is an open discretionary opportunity from National Institutes of Health, offering Varies by applicant across 3 expected awards. Applications close in 850 days. PlainGrants indexes 12,419 other opportunities from National Institutes of Health.

Varies
award range
Open
850 days left
3
expected awards
93.213;93.233;93.273;93.279;93.395;93.837;93.838;93.839;93.840;93.846;93.853;93.865;93.866;93.867
CFDA program

Open desk with published close date

HEAL Initiative: Non-addictive Analgesic Ther… remains open until February 20, 2029 (850 days out). Award range Varies by applicant without a cost-share requirement.

According to Grants.gov (extract vintage 2026-08-10), this record reflects the officially published listing. See methodology.

Deadline tracker

850 days left to apply

Posted Jun 16 → closes Feb 20, 2029

Posted Jun 16 Closes Feb 20

Est. Total Funding

$11,000,000

Expected Awards

3

Instrument

Cooperative Agreement

Description

The purpose of this Notice of Funding Opportunity (NOFO) is to support the preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics for the treatment of pain. The goal of the program is to accelerate the advancement of promising early-stage therapeutic candidates and facilitate their readiness for Phase II clinical trials. Applicants must have a promising small molecule or biologic lead candidate for optimization, a strong biological rationale for the proposed approach, and established assays to guide the optimization process. The scope of the program includes lead optimization, early-stage development activities, IND-enabling studies, development of pharmacodynamic and/or target engagement biomarkers, preparation and submission of an Investigational New Drug (IND) application, and Phase I clinical testing. This is a milestone-driven, phased cooperative agreement program that involves active participation by NIH program staff in project planning and ongoing monitoring of research progress.

Wide-open applicant board · 15 Grants.gov doors

HEAL Initiative: Non-addictive Analgesic Ther… prints 15 distinct Grants.gov eligibility doors (State governments; County governments; City or township governments; Special district governments; +11 more). Filter fit before reading award size as demand — most applicant classes appear on the row. The extract does not mark applicant cost-sharing as required. Instrument: Cooperative Agreement. Funding-activity code maps to Health (HL). This eligibility-code string dominates the National Institutes of Health book (9,741 peers, 78% of 12,420).

Code 00
State governments
Code 01
County governments
Code 02
City or township governments
Code 04
Special district governments
Code 05
Independent school districts
Code 06
Public / state-controlled institutions of higher education
Code 07
Federally recognized tribal governments
Code 08
Public / Indian housing authorities
Code 11
Native American tribal organizations (other than Federally recognized tribal governments)
Code 12
Nonprofits with 501(c)(3) status (other than IHEs)
Code 13
Nonprofits without 501(c)(3) status (other than IHEs)
Code 20
Private institutions of higher education
Code 22
For-profit organizations other than small businesses
Code 23
Small businesses
Code 25
Others (see official listing text)

Codes are Grants.gov eligibility category values from the extract vintage 2026-08-10. Confirm the full eligibility statement on the official listing or the Grants.gov eligibility reference.

Official Listing on Grants.gov

View full details, application forms, and submission instructions.

View on Grants.gov

Agency Contact

National Institute of Neurological Disorders and Stroke (NINDS) PTDP@ninds.nih.gov

What to do next

HEAL Initiative: Non-addictive Analgesic Ther… is open with Varies by applicant awards and 850 days left on the clock.

  • Submit through Grants.gov (RFA-NS-27-007) - verify SAM.gov registration and the current NOFO before drafting. Official listing
  • Look up CFDA 93.213;93.233;93.273;93.279;93.395;93.837;93.838;93.839;93.840;93.846;93.853;93.865;93.866;93.867 across all indexed listings before you commit to this opportunity alone. Eligibility finder
  • National Institutes of Health lists 12,419 other indexed opportunities on PlainGrants. Agency catalog

Opportunity deadlines and eligibility change on Grants.gov; PlainGrants mirrors the extract and is not the submission system.

Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.

Data sourced from the SAM.gov Assistance Listings and Grants.gov. See our methodology for details. Retrieved and formatted by PlainGrants