Open · PA-27-101 · CFDA 93.233;93.242;93.273;93.307;93.313;93.350;93.351;93.393;93.394;93.395;93.837;93.838;93.839;93.840;93.847;93.853;93.855;93.859;93.865;93.866;93.867 · Discretionary

NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)

Federal grant opportunity posted by National Institutes of Health, cataloged on Grants.gov.

Varies
Award range
Open
Status
894d
Days left
-
Expected awards

The verdict

NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) is an open discretionary opportunity from National Institutes of Health, offering Varies by applicant. Applications close in 894 days. PlainGrants indexes 12,419 other opportunities from National Institutes of Health.

Varies
award range
Open
894 days left
93.233;93.242;93.273;93.307;93.313;93.350;93.351;93.393;93.394;93.395;93.837;93.838;93.839;93.840;93.847;93.853;93.855;93.859;93.865;93.866;93.867
CFDA program
12,419
other opportunities from National Institutes of Health

Open desk with published close date

NIH Small Business Innovation Research remains open until April 5, 2029 (894 days out). Award range Varies by applicant with required cost sharing.

According to Grants.gov (extract vintage 2026-08-10), this record reflects the officially published listing. See methodology.

Deadline tracker

894 days left to apply

Posted May 28 → closes Apr 5, 2029

Posted May 28 Closes Apr 5

Instrument

Grant

Cost Sharing

Required

Description

The NIH Phase IIB Strategic Breakthrough award bridges the funding gap between the end of a Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II award and commercialization. The Phase IIB Strategic Breakthrough provides previously funded NIH SBIR or STTR projects additional support for later-stage research and development (R&D).

Small-business / for-profit corridor · PA-27-101

NIH Small Business Innovation Research prints a for-profit / small-business applicant door (Small businesses). Treat the listing as business-facing unless the full Grants.gov announcement narrows it further. Applicant cost-sharing is required on the Grants.gov extract. Instrument: Grant. Funding-activity code maps to Health (HL). 789 other National Institutes of Health listings share this eligibility-code string (6% of 12,420).

Code 23
Small businesses

Codes are Grants.gov eligibility category values from the extract vintage 2026-08-10. Confirm the full eligibility statement on the official listing or the Grants.gov eligibility reference.

Official Listing on Grants.gov

View full details, application forms, and submission instructions.

View on Grants.gov

Agency Contact

NIH SEED (Small business Education and Entrepreneurial Development) SEEDinfo@nih.gov

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What to do next

NIH Small Business Innovation Research is open with Varies by applicant awards and 894 days left on the clock.

  • Submit through Grants.gov (PA-27-101) - verify SAM.gov registration and the current NOFO before drafting. Official listing
  • Look up CFDA 93.233;93.242;93.273;93.307;93.313;93.350;93.351;93.393;93.394;93.395;93.837;93.838;93.839;93.840;93.847;93.853;93.855;93.859;93.865;93.866;93.867 across all indexed listings before you commit to this opportunity alone. Eligibility finder
  • National Institutes of Health lists 12,419 other indexed opportunities on PlainGrants. Agency catalog

Opportunity deadlines and eligibility change on Grants.gov; PlainGrants mirrors the extract and is not the submission system.

Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.

Read our methodology - how this data is sourced, computed, and verified.

Data sourced from the SAM.gov Assistance Listings and Grants.gov. See our methodology for details. Retrieved and formatted by PlainGrants