Open · RFA-OD-27-004 · CFDA 93.121;93.173;93.233;93.242;93.310;93.350;93.351;93.395;93.837;93.838;93.839;93.840;93.846;93.847;93.855;93.865;93.866;93.867;93.879 · Discretionary
INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)
Federal grant opportunity posted by National Institutes of Health, cataloged on Grants.gov.
- up to $500K
- Award range
- Open
- Status
- 672d
- Days left
- 4
- Expected awards
The verdict
INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed) is an open discretionary opportunity from National Institutes of Health, offering Up to $500,000 across 4 expected awards. Applications close in 672 days.
- up to $500K
- award range
- Open
- 672 days left
- 4
- expected awards
- 93.121;93.173;93.233;93.242;93.310;93.350;93.351;93.395;93.837;93.838;93.839;93.840;93.846;93.847;93.855;93.865;93.866;93.867;93.879
- CFDA program
Opportunity snapshot. This Grants.gov announcement - INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed) - is cataloged under number RFA-OD-27-004 and tied to CFDA assistance listing 93.121;93.173;93.233;93.242;93.310;93.350;93.351;93.395;93.837;93.838;93.839;93.840;93.846;93.847;93.855;93.865;93.866;93.867;93.879, posted by National Institutes of Health. Grants.gov currently shows the opportunity as open, first posted on May 12, 2026. The funding category is Discretionary, delivered as a grant.
Award economics. The award range on file is Up to $500,000. The agency has projected $3.0 million in total estimated funding for this announcement. It expects to issue 4 awards. If the agency funds the expected 4 awards from the $3.0 million estimated pool, the average award works out to roughly $750,000. Cost sharing is not required, so applicants do not need to commit matching funds to be competitive on this opportunity. Federal award ranges are often upper bounds; actual allocations reflect program appropriations, the strength of the applicant pool, and the evaluation committee's scoring.
Deadline and action path. Applications close on June 15, 2028 - roughly 672 days from today. Every Grants.gov submission requires an active SAM.gov registration and a Unique Entity ID. Review the Eligibility section below carefully, federal eligibility categories (nonprofit, state or local government, tribal, individual, educational institution, small business) have distinct registration and reporting requirements. Pre-application outreach to the listed agency contact is permitted and often welcomed, it helps clarify scope and scoring priorities. Before acting on the deadline or award figures above, verify them directly on the official Grants.gov listing, amendments can change dates and amounts after this page was last refreshed.
Award Range
Up to $500,000
Close Date
June 15, 2028
Posted
May 12, 2026
Est. Total Funding
$3,000,000
Expected Awards
4
Instrument
Grant
Description
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.
Eligibility
Grants.gov lists this opportunity under eligibility category codes 00, 01, 02, 04, 05, 06, 07, 08, 11, 12, 13, 20, 22, 23, 25. These codes correspond to applicant types (state/local government, tribal organization, nonprofit, educational institution, individual, small business, etc.) defined in Grants.gov's own eligibility reference. See the current Grants.gov eligibility categories or check the official listing below for this opportunity's exact eligibility statement.
Official Listing on Grants.gov
View full details, application forms, and submission instructions.
Agency Contact
The INCLUDE Project DownSyndromeINCLUDE@mail.nih.gov
Key Dates
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Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.
Read our methodology - how this data is sourced, computed, and verified.
Related
| Publisher | PlainGrants |
| Sources | the SAM.gov Assistance Listings and Grants.gov |