Open · RFA-OD-27-005 · CFDA 93.173;93.233;93.310;93.350;93.395;93.837;93.838;93.839;93.840;93.846;93.847;93.865;93.866 · Discretionary

INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)

Federal grant opportunity posted by National Institutes of Health, cataloged on Grants.gov.

Varies
Award range
Open
Status
600d
Days left
4
Expected awards

The verdict

INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required) is an open discretionary opportunity from National Institutes of Health, offering Varies by applicant across 4 expected awards. Applications close in 600 days. PlainGrants indexes 12,419 other opportunities from National Institutes of Health.

Varies
award range
Open
600 days left
4
expected awards
93.173;93.233;93.310;93.350;93.395;93.837;93.838;93.839;93.840;93.846;93.847;93.865;93.866
CFDA program

Open desk with published close date

INCLUDE Project: Clinical Trials Phased Award… remains open until June 15, 2028 (600 days out). Award range Varies by applicant without a cost-share requirement.

According to Grants.gov (extract vintage 2026-08-10), this record reflects the officially published listing. See methodology.

Deadline tracker

600 days left to apply

Posted May 13 → closes Jun 15, 2028

Posted May 13 Closes Jun 15

Est. Total Funding

$3,000,000

Expected Awards

4

Instrument

Grant

Description

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) encourages Exploratory/Developmental Phased Innovation (R61/R33) grant applications to support development of clinical trials to treat critical and co-occurring health conditions in individuals with Down syndrome. The proposed research aims should be milestone-driven. The total project period for an application submitted in response to this NOFO may not exceed five years. This NOFO provides support for up to two years (R61 phase) for preliminary/developmental/planning studies, followed by possible transition to clinical trial support (R33) of up to three years, although the total duration of the award may not exceed five years. This NOFO requires measurable R61 milestones.

Wide-open applicant board · 15 Grants.gov doors

INCLUDE Project: Clinical Trials Phased Award… prints 15 distinct Grants.gov eligibility doors (State governments; County governments; City or township governments; Special district governments; +11 more). Filter fit before reading award size as demand — most applicant classes appear on the row. The extract does not mark applicant cost-sharing as required. Instrument: Grant. Funding-activity code maps to Health (HL). This eligibility-code string dominates the National Institutes of Health book (9,741 peers, 78% of 12,420).

Code 00
State governments
Code 01
County governments
Code 02
City or township governments
Code 04
Special district governments
Code 05
Independent school districts
Code 06
Public / state-controlled institutions of higher education
Code 07
Federally recognized tribal governments
Code 08
Public / Indian housing authorities
Code 11
Native American tribal organizations (other than Federally recognized tribal governments)
Code 12
Nonprofits with 501(c)(3) status (other than IHEs)
Code 13
Nonprofits without 501(c)(3) status (other than IHEs)
Code 20
Private institutions of higher education
Code 22
For-profit organizations other than small businesses
Code 23
Small businesses
Code 25
Others (see official listing text)

Codes are Grants.gov eligibility category values from the extract vintage 2026-08-10. Confirm the full eligibility statement on the official listing or the Grants.gov eligibility reference.

Official Listing on Grants.gov

View full details, application forms, and submission instructions.

View on Grants.gov

Agency Contact

The INCLUDE Project DownSyndromeINCLUDE@mail.nih.gov

What to do next

INCLUDE Project: Clinical Trials Phased Award… is open with Varies by applicant awards and 600 days left on the clock.

  • Submit through Grants.gov (RFA-OD-27-005) - verify SAM.gov registration and the current NOFO before drafting. Official listing
  • Look up CFDA 93.173;93.233;93.310;93.350;93.395;93.837;93.838;93.839;93.840;93.846;93.847;93.865;93.866 across all indexed listings before you commit to this opportunity alone. Eligibility finder
  • National Institutes of Health lists 12,419 other indexed opportunities on PlainGrants. Agency catalog

Opportunity deadlines and eligibility change on Grants.gov; PlainGrants mirrors the extract and is not the submission system.

Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.

Data sourced from the SAM.gov Assistance Listings and Grants.gov. See our methodology for details. Retrieved and formatted by PlainGrants