Open · DE-FOA-0003612 · CFDA 81.049 · Discretionary

The Genesis Mission: Transforming Science and Energy with AI

Federal grant opportunity posted by Office of Science, cataloged on Grants.gov.

$500K-$16M
Award range
Open
Status
97d
Days left
-
Expected awards

The verdict

The Genesis Mission: Transforming Science and Energy with AI is an open discretionary opportunity from Office of Science, offering $500,000 -- $16,000,000. Applications close in 97 days. PlainGrants indexes 414 other opportunities from Office of Science.

$500K-$16M
award range
Open
97 days left
81.049
CFDA program
414
other opportunities from Office of Science

Open desk with published close date

The Genesis Mission: Transforming Science and… remains open until December 17, 2026 (97 days out). Mega-scale award ceiling ($500,000 -- $16,000,000) with required cost sharing. Parent CFDA 81.049 may carry future cycles if this NOFO closes unfunded.

According to Grants.gov (extract vintage 2026-08-10), this record reflects the officially published listing. See methodology.

Deadline tracker

97 days left to apply

Posted Mar 17 → closes Dec 17, 2026

Posted Mar 17 Closes Dec 17

Est. Total Funding

$293,760,000

Instrument

Other

Cost Sharing

Required

Description

The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud. DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions). In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.

Catch-all / unrestricted eligibility mark · DE-FOA-0003612

Grants.gov marks The Genesis Mission: Transforming Science and… with a catch-all / unrestricted eligibility code (Unrestricted / see official listing). Read the official announcement text for the real applicant filter — the code alone is not a door list. Applicant cost-sharing is required on the Grants.gov extract. Instrument: Other. Funding-activity code maps to Science and Technology / R&D (ST). This eligibility-code string dominates the Office of Science book (278 peers, 67% of 415).

Code 99
Unrestricted / see official listing

Codes are Grants.gov eligibility category values from the extract vintage 2026-08-10. Confirm the full eligibility statement on the official listing or the Grants.gov eligibility reference.

Official Listing on Grants.gov

View full details, application forms, and submission instructions.

View on Grants.gov

Parent Grant Program

CFDA 81.049

Basic Energy Sciences

U.S. Department of Energy

View program →

Agency Contact

GenesisMissionNOFO@science.doe.gov

More from Office of Science

Open Closes September 30, 2026

FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program

View →

What to do next

The Genesis Mission: Transforming Science and… is open with $500,000 -- $16,000,000 awards and 97 days left on the clock.

  • Submit through Grants.gov (DE-FOA-0003612) - verify SAM.gov registration and the current NOFO before drafting. Official listing
  • Basic Energy Sciences indexes 6 Grants.gov listings in this extract. Program profile
  • Office of Science lists 414 other indexed opportunities on PlainGrants. Agency catalog

Opportunity deadlines and eligibility change on Grants.gov; PlainGrants mirrors the extract and is not the submission system.

Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.

Read our methodology - how this data is sourced, computed, and verified.

Data sourced from the SAM.gov Assistance Listings and Grants.gov. See our methodology for details. Retrieved and formatted by PlainGrants