NINR Areas of Emphasis for Research to Optimize Health and Advance Health for All (R21 Clinical Trial Optional)

Opportunity snapshot. This Grants.gov announcement — NINR Areas of Emphasis for Research to Optimize Health and Advance Health for All (R21 Clinical Trial Optional) — is cataloged under number PAR-22-231 and tied to CFDA assistance listing 93.361, posted by National Institutes of Health. Grants.gov currently shows the opportunity as closed, first posted on September 9, 2022 and last updated on March 25, 2025. The funding category is Discretionary, delivered as a grant.

Award economics. The award range on file is Varies by applicant. Cost sharing is not required, so applicants do not need to commit matching funds to be competitive on this opportunity. Federal award ranges are often upper bounds; actual allocations reflect program appropriations, the strength of the applicant pool, and the evaluation committee's scoring.

Deadline and action path. This opportunity closed on May 7, 2025. Future funding cycles may be published under the same CFDA number, so monitoring the parent program page is the most reliable way to catch re-announcements. Every Grants.gov submission requires an active SAM.gov registration and a Unique Entity ID. Review the Eligibility section below carefully — federal eligibility categories (nonprofit, state or local government, tribal, individual, educational institution, small business) have distinct registration and reporting requirements. Pre-application outreach to the listed agency contact is permitted and often welcomed — it helps clarify scope and scoring priorities.