Closed · RFA-NS-25-014 · CFDA 93.853;93.866 · Discretionary
Mechanisms of Cognitive Fluctuations in ADRD Populations (R01 - Clinical Trial Optional)
Federal grant opportunity posted by National Institutes of Health, cataloged on Grants.gov.
- up to $825K
- Award range
- Closed
- Status
- June 24, 2024
- Close date
- -
- Expected awards
The verdict
Mechanisms of Cognitive Fluctuations in ADRD Populations (R01 - Clinical Trial Optional) is a closed discretionary listing from National Institutes of Health that offered Up to $825,000. Future funding cycles may be published under the same CFDA number.
- up to $825K
- award range
- Closed
- application status
- 93.853;93.866
- CFDA program
Opportunity snapshot. This Grants.gov announcement - Mechanisms of Cognitive Fluctuations in ADRD Populations (R01 - Clinical Trial Optional) - is cataloged under number RFA-NS-25-014 and tied to CFDA assistance listing 93.853;93.866, posted by National Institutes of Health. Grants.gov currently shows the opportunity as closed, first posted on March 18, 2024. The funding category is Discretionary, delivered as a grant.
Award economics. The award range on file is Up to $825,000. Cost sharing is not required, so applicants do not need to commit matching funds to be competitive on this opportunity. Federal award ranges are often upper bounds; actual allocations reflect program appropriations, the strength of the applicant pool, and the evaluation committee's scoring.
Deadline and action path. This opportunity closed on June 24, 2024. Future funding cycles may be published under the same CFDA number, so monitoring the parent program page is the most reliable way to catch re-announcements. Every Grants.gov submission requires an active SAM.gov registration and a Unique Entity ID. Review the Eligibility section below carefully, federal eligibility categories (nonprofit, state or local government, tribal, individual, educational institution, small business) have distinct registration and reporting requirements. Pre-application outreach to the listed agency contact is permitted and often welcomed, it helps clarify scope and scoring priorities. Before acting on the deadline or award figures above, verify them directly on the official Grants.gov listing, amendments can change dates and amounts after this page was last refreshed.
Award Range
Up to $825,000
Close Date
June 24, 2024
Posted
March 18, 2024
Instrument
Grant
Description
"Fluctuating cognition can occur in many types of dementia and is a core clinical feature of Dementia with Lewy Bodies. Cognitive fluctuations can last from seconds to days, are unpredictable (e.g., do not just occur in the evenings, as with sun-downing), and are associated with poor daily functioning for the patient. A number of small studies have suggested that cognitive fluctuations in subjects with dementia may be related to epileptiform discharges and impaired oscillatory activity on EEG, but it is not clear that these are the only factors involved in patient populations that often experience dysautonomia, orthostasis, and sleep disturbances. The etiology of cognitive fluctuations may be multi-factorial and may vary in different dementia populations. Understanding the physiology related to cognitive fluctuations is a critical next step to the development of treatment approaches and improving quality of life for these patients. This initiate would encourage research that will better characterize the physiology responsible for cognitive fluctuations in ADRD populations. Given their variable appearance and time course, it is anticipated that wearable digital devices will be important for capturing fluctuations in a timely fashion, and applicants should consider incorporating those device(s) capable of acquiring the relevant data to support the hypothesized mechanism(s). Applicants may focus on assessing multiple mechanisms in a specific ADRD population, or may chose to compare mechanisms across multiple types of ADRDs. "
Eligibility
Grants.gov lists this opportunity under eligibility category codes 00, 01, 02, 04, 05, 06, 07, 08, 11, 12, 13, 20, 22, 23, 25. These codes correspond to applicant types (state/local government, tribal organization, nonprofit, educational institution, individual, small business, etc.) defined in Grants.gov's own eligibility reference. See the current Grants.gov eligibility categories or check the official listing below for this opportunity's exact eligibility statement.
Official Listing on Grants.gov
View full details, application forms, and submission instructions.
Agency Contact
NIH Grants Information grantsinfo@nih.gov
Key Dates
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| Sources | the SAM.gov Assistance Listings and Grants.gov |