Open PAR-25-101 CFDA 93.279 Discretionary

Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)

Posted by National Institutes of Health

Opportunity snapshot. This Grants.gov announcement — Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional) — is cataloged under number PAR-25-101 and tied to CFDA assistance listing 93.279, posted by National Institutes of Health. Grants.gov currently shows the opportunity as open, first posted on December 30, 2024 and last updated on March 31, 2025. The funding category is Discretionary, delivered as a grant.

Award economics. The award range on file is Up to $150,000. The agency has projected $150,000 in total estimated funding for this announcement. Cost sharing is not required, so applicants do not need to commit matching funds to be competitive on this opportunity. Federal award ranges are often upper bounds; actual allocations reflect program appropriations, the strength of the applicant pool, and the evaluation committee's scoring.

Deadline and action path. Applications close on August 11, 2027 — roughly 432 days from today. Every Grants.gov submission requires an active SAM.gov registration and a Unique Entity ID. Review the Eligibility section below carefully — federal eligibility categories (nonprofit, state or local government, tribal, individual, educational institution, small business) have distinct registration and reporting requirements. Pre-application outreach to the listed agency contact is permitted and often welcomed — it helps clarify scope and scoring priorities.

Award Range

Up to $150,000

Close Date

August 11, 2027

Posted

December 30, 2024

Est. Total Funding

$150,000

Instrument

Grant

Description

The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology, prevention, or treatment of substance use disorders (SUDs). It supports high-risk and potentially high-impact research that is sparse or not included in NIDA's current portfolio that has the potential to transform SUD research. The proposed research should: 1. develop, and/or adapt, revolutionary techniques or methods for addiction research or that show promising future applicability to SUD research; and /or 2. test an innovative and significant hypothesis for which there are scant precedent or preliminary data and which, if confirmed, would transform current thinking.

Eligibility

00;01;02;04;05;06;07;08;11;12;13;20;22;23;25

Official Listing on Grants.gov

View full details, application forms, and submission instructions.

View on Grants.gov

Agency Contact

NIH Grants Information <br/>grantsinfo@nih.gov

Key Dates

Posted December 30, 2024
Close Date August 11, 2027
Archive Date September 16, 2027
Last Updated March 31, 2025

Frequently Asked Questions

What is this grant opportunity?
This is a federal funding opportunity titled "Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)", offered by National Institutes of Health. It is associated with CFDA program 93.279. The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology...
Is this opportunity still open?
Yes, this opportunity is currently open for applications. The closing date is August 11, 2027.
How much funding is available?
The award range for this opportunity is Up to $150,000. Total estimated funding: $150,000.
How do I apply?
Applications for federal grant opportunities are typically submitted through Grants.gov. Visit the official listing at grants.gov for application instructions, required documents, and submission deadlines.

Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainGrants Editorial