| Early Learning Alignment and Improvement Grants CFDA 84.411 | U.S. Department of Education | $25.0M |
| Early Reading First CFDA 84.348 | U.S. Department of Education | $3.0M |
| Economic Adjustment Assistance CFDA 11.307 | U.S. Department of Commerce | $5.0M |
| Economic Adjustment for Coal Communities CFDA 11.558 | U.S. Department of Commerce | $5.0M |
| Economic Development Assistance Programs CFDA 11.010 | U.S. Department of Commerce | $5.0M |
| Economic Development Technical Assistance Program CFDA 11.302 | U.S. Department of Commerce | $1.0M |
| Economic Development — Technical Assistance CFDA 11.305 | U.S. Department of Commerce | $500K |
| Education for Homeless Children and Youths CFDA 84.196 | U.S. Department of Education | $2.0M |
| Education Research and Development CFDA 84.305 | U.S. Department of Education | $3.0M |
| Educational Exchange — Fulbright Program CFDA 19.020 | U.S. Department of State | $100K |
| Emergency Management Performance Grants (EMPG) CFDA 97.042 | Federal Emergency Management Agency | $5.0M |
| Emergency Solutions Grants CFDA 14.231 | U.S. Department of Housing and Urban Development | $5.0M |
| Emergency Watershed Protection Program CFDA 10.604 | U.S. Department of Agriculture | $5.0M |
| Employment Service CFDA 17.207 | U.S. Department of Labor | $20.0M |
| Empowering Communities with Alzheimer's CFDA 93.734 | U.S. Department of Health and Human Services | $3.0M |
| Energy Efficiency and Renewable Energy Research CFDA 81.127 | U.S. Department of Energy | $5.0M |
| Energy Storage Technologies CFDA 81.117 | U.S. Department of Energy | $10.0M |
| Engineering Grants CFDA 47.041 | National Science Foundation | $3.0M |
| English Language Acquisition State Grants CFDA 84.365 | U.S. Department of Education | $5.0M |
| Enhanced Mobility of Seniors and Individuals with Disabilities CFDA 20.513 | U.S. Department of Transportation | $5.0M |
| Enhanced Mobility of Seniors in Rural Areas CFDA 20.527 | U.S. Department of Transportation | $3.0M |
| Entrepreneurship Education and Training CFDA 59.074 | U.S. Small Business Administration | $1.0M |
| Environmental Cleanup CFDA 81.135 | U.S. Department of Energy | $20.0M |
| Environmental Justice Collaborative Problem Solving CFDA 66.306 | U.S. Environmental Protection Agency | $1.0M |
| Environmental Justice Collaborative Problem-Solving CFDA 66.604 | U.S. Environmental Protection Agency | $1.0M |
| Environmental Justice Programs CFDA 93.070 | U.S. Department of Health and Human Services | $2.0M |
| Environmental Quality Incentive Program — Organic Transition CFDA 10.612 | U.S. Department of Agriculture | $50K |
| Environmental Quality Incentives Program (EQIP) CFDA 10.912 | U.S. Department of Agriculture | $450K |
| Even Start Family Literacy CFDA 84.287 | U.S. Department of Education | $3.0M |
| Exploration Systems Research and Development CFDA 43.003 | National Aeronautics and Space Administration | $2.0M |
| Export Control and Border Security CFDA 19.033 | U.S. Department of State | $5.0M |