| Schools and Roads Payments to Counties CFDA 10.668 | U.S. Department of Agriculture | Agriculture | $5.0M |
| Schools and Roads — Grants to States CFDA 10.960 | U.S. Department of Agriculture | Agriculture | $5.0M |
| Science to Achieve Results (STAR) CFDA 66.509 | U.S. Environmental Protection Agency | Environment | $2.0M |
| Sea Grant Aquaculture Research CFDA 11.460 | National Oceanic and Atmospheric Administration | Agriculture | $1.0M |
| Sea Grant Support CFDA 11.417 | National Oceanic and Atmospheric Administration | Science & Research | $5.0M |
| Second Chance Act Reentry Initiative CFDA 16.812 | U.S. Department of Justice | Public Safety | $2.5M |
| Section 108 Loan Guarantee Program CFDA 14.258 | U.S. Department of Housing and Urban Development | Housing | $35.0M |
| Section 4 Capacity Building for Community Development CFDA 14.252 | U.S. Department of Housing and Urban Development | Housing | $10.0M |
| Section 8 Housing Assistance Payments CFDA 14.195 | U.S. Department of Housing and Urban Development | Housing | $50.0M |
| Section 8 Housing Choice Vouchers CFDA 14.871 | U.S. Department of Housing and Urban Development | Housing | $100.0M |
| Senior Community Service Employment Program CFDA 17.235 | U.S. Department of Labor | Education | $20.0M |
| Senior Companions Program CFDA 93.641 | AmeriCorps | Health | $1.0M |
| Senior Demonstration Programs CFDA 94.016 | AmeriCorps | Health | $2.0M |
| Service Coordinators in Multifamily Housing CFDA 14.267 | U.S. Department of Housing and Urban Development | Housing | $500K |
| Services for Victims of Trafficking CFDA 16.518 | U.S. Department of Justice | Public Safety | $2.0M |
| Sexual Assault Services Formula Program CFDA 16.017 | U.S. Department of Justice | Public Safety | $5.0M |
| Small Business Administration Disaster Loans CFDA 59.048 | U.S. Small Business Administration | Business & Economic Development | $2.0M |
| Small Business Development Center Grants CFDA 59.037 | U.S. Small Business Administration | Business & Economic Development | $5.0M |
| Small Business Innovation Research (SBA) CFDA 59.057 | U.S. Small Business Administration | Business & Economic Development | $1.5M |
| Small Business Investment Companies CFDA 59.030 | U.S. Small Business Administration | Business & Economic Development | $50.0M |
| Small Business Technology Transfer (SBA) CFDA 59.058 | U.S. Small Business Administration | Business & Economic Development | $1.0M |
| Social, Behavioral, and Economic Sciences CFDA 47.075 | National Science Foundation | Science & Research | $2.0M |
| Soil and Water Conservation Programs CFDA 10.902 | U.S. Department of Agriculture | Agriculture | $2.0M |
| Solid Waste Management Assistance Grants CFDA 66.708 | U.S. Environmental Protection Agency | Environment | $500K |
| Space Science Research CFDA 43.007 | National Aeronautics and Space Administration | Science & Research | $5.0M |
| Special Education Grants to States (IDEA Part B) CFDA 84.027 | U.S. Department of Education | Education | $100.0M |
| Special Education Preschool Grants CFDA 84.173 | U.S. Department of Education | Education | $10.0M |
| Special Programs for Aging — Congregate Nutrition CFDA 93.044 | U.S. Department of Health and Human Services | Health | $5.0M |
| Special Programs for Aging — Home Delivered Nutrition CFDA 93.045 | U.S. Department of Health and Human Services | Health | $3.0M |
| Special Programs for Aging — Native Americans CFDA 93.042 | U.S. Department of Health and Human Services | Health | $2.0M |
| Special Programs for the Aging CFDA 93.110 | U.S. Department of Health and Human Services | Health | $5.0M |
| Special Programs for the Aging — Nutrition Services CFDA 93.043 | U.S. Department of Health and Human Services | Health | $5.0M |
| Specialty Crop Block Grant Program CFDA 10.170 | U.S. Department of Agriculture | Agriculture | $2.0M |
| Sport Fish Restoration Program CFDA 15.605 | U.S. Department of the Interior | Environment | $20.0M |
| Staffing for Adequate Fire and Emergency Response (SAFER) CFDA 97.045 | Federal Emergency Management Agency | Public Safety | $2.0M |
| State and Community Highway Safety CFDA 20.600 | U.S. Department of Transportation | Transportation | $20.0M |
| State and Local Implementation Grant Program CFDA 97.043 | Federal Emergency Management Agency | Public Safety | $5.0M |
| State Energy Program CFDA 81.041 | U.S. Department of Energy | Science & Research | $10.0M |
| State Indoor Radon Grants CFDA 66.032 | U.S. Environmental Protection Agency | Environment | $1.0M |
| State of Good Repair Grants CFDA 20.525 | U.S. Department of Transportation | Transportation | $50.0M |
| State Trade Expansion Program (STEP) CFDA 11.549 | U.S. Department of Commerce | Business & Economic Development | $2.0M |
| STEM Education Grants CFDA 47.076 | National Science Foundation | Science & Research | $3.0M |
| STOP (Services Training Officers Prosecutors) Violence Against Women CFDA 16.017 | U.S. Department of Justice | Public Safety | $10.0M |
| Striving Readers CFDA 84.362 | U.S. Department of Education | Education | $25.0M |
| Substance Abuse and Mental Health Services (SAMHSA) CFDA 93.243 | U.S. Department of Health and Human Services | Health | $5.0M |
| Summer Stipends for Humanities Research CFDA 45.161 | National Endowment for the Humanities | Arts & Culture | $6K |
| Supported Employment Services for Individuals with Severe Disabilities CFDA 84.181 | U.S. Department of Education | Education | $5.0M |
| Supportive Housing Program CFDA 14.235 | U.S. Department of Housing and Urban Development | Housing | $5.0M |
| Surveys, Studies, Research, Investigations, Demonstrations, and Special Purpose Activities CFDA 66.034 | U.S. Environmental Protection Agency | Environment | $2.0M |
| Surveys, Studies, Training, and Demonstrations CFDA 66.309 | U.S. Environmental Protection Agency | Environment | $2.0M |