The Genesis Mission: Transforming Science and Energy with AI
Posted by Office of Science
Opportunity snapshot. This Grants.gov announcement — The Genesis Mission: Transforming Science and Energy with AI — is cataloged under number DE-FOA-0003612 and tied to CFDA assistance listing 81.049, posted by Office of Science. Grants.gov currently shows the opportunity as open, first posted on March 17, 2026 and last updated on March 31, 2026. The funding category is Discretionary, delivered as a other.
Award economics. The award range on file is $500,000 -- $5,000,000. The agency has projected $293.8 million in total estimated funding for this announcement. Cost sharing or matching funds are required, meaning applicants must contribute a portion of the project budget from non-federal sources — factor this into your financial plan before drafting the proposal. Federal award ranges are often upper bounds; actual allocations reflect program appropriations, the strength of the applicant pool, and the evaluation committee's scoring.
Deadline and action path. Applications close on December 17, 2026 — roughly 195 days from today. Every Grants.gov submission requires an active SAM.gov registration and a Unique Entity ID. Review the Eligibility section below carefully — federal eligibility categories (nonprofit, state or local government, tribal, individual, educational institution, small business) have distinct registration and reporting requirements. Pre-application outreach to the listed agency contact is permitted and often welcomed — it helps clarify scope and scoring priorities.
Award Range
$500,000 -- $5,000,000
Close Date
December 17, 2026
Posted
March 17, 2026
Est. Total Funding
$293,760,000
Instrument
Other
Cost Sharing
Required
Description
The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud. DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions). In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.
Eligibility
99
Official Listing on Grants.gov
View full details, application forms, and submission instructions.
Parent Grant Program
Basic Energy Sciences
U.S. Department of Energy
Agency Contact
GenesisMissionNOFO@science.doe.gov
Key Dates
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Disclaimer: This information is sourced from Grants.gov and SAM.gov and is for informational purposes only. Opportunity details, deadlines, and eligibility requirements change frequently. Always verify current information directly on Grants.gov before applying. PlainGrants is not affiliated with any federal agency.
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