| Continuum of Care (CoC) Program CFDA 14.895 | U.S. Department of Housing and Urban Development | Housing | $10.0M |
| Convergence Accelerators CFDA 47.041 | National Science Foundation | Science & Research | $5.0M |
| Cooperative Endangered Species Conservation Fund CFDA 15.250 | U.S. Department of the Interior | Environment | $10.0M |
| Cooperative Extension Service CFDA 10.500 | U.S. Department of Agriculture | Agriculture | $10.0M |
| Cooperative Research Partnership Grants CFDA 10.918 | U.S. Department of Agriculture | Agriculture | $1.0M |
| Coordinated School Health Program CFDA 93.697 | Centers for Disease Control and Prevention | Health | $3.0M |
| Coordinated Services and Access to Research for Women CFDA 93.153 | U.S. Department of Health and Human Services | Health | $3.0M |
| COPS Hiring Program CFDA 16.839 | U.S. Department of Justice | Public Safety | $1.0M |
| Corrections Technical Assistance CFDA 16.527 | U.S. Department of Justice | Public Safety | $1.0M |
| Creative Forces Grants CFDA 45.024 | National Endowment for the Arts | Arts & Culture | $200K |
| Crime Victim Assistance (VOCA) CFDA 16.575 | U.S. Department of Justice | Public Safety | $50.0M |
| Crisis Intervention Team Programs CFDA 16.614 | U.S. Department of Justice | Public Safety | $1.0M |
| Critical Materials Research and Development CFDA 81.089 | U.S. Department of Energy | Science & Research | $5.0M |
| Crop Protection and Pest Management CFDA 10.458 | U.S. Department of Agriculture | Agriculture | $2.0M |
| Demolition and Revitalization of Severely Distressed Housing CFDA 14.866 | U.S. Department of Housing and Urban Development | Housing | $50.0M |
| Demonstration Grants for Indian Children CFDA 84.316 | U.S. Department of Education | Education | $1.0M |
| Diabetes, Endocrine, and Metabolic Disease Research CFDA 93.847 | National Institutes of Health | Health | $3.0M |
| Diesel Emission Reduction Grants CFDA 66.039 | U.S. Environmental Protection Agency | Environment | $2.0M |
| Digital Humanities Advancement Grants CFDA 45.149 | National Endowment for the Humanities | Arts & Culture | $150K |
| Disability Employment Initiative CFDA 17.261 | U.S. Department of Labor | Education | $5.0M |
| Disaster Assistance Loans for Non-Farm Businesses CFDA 59.025 | U.S. Small Business Administration | Business & Economic Development | $2.0M |
| Discovery Research for Cancer Diagnostics CFDA 93.286 | National Institutes of Health | Health | $3.0M |
| Disposal of Coal Combustion Residuals CFDA 66.200 | U.S. Environmental Protection Agency | Environment | $2.0M |
| Distance Learning and Telemedicine Grants CFDA 10.855 | U.S. Department of Agriculture | Agriculture | $1.0M |
| Distressed Areas Program CFDA 11.558 | U.S. Department of Commerce | Business & Economic Development | $20.0M |
| Distressed Cities Technical Assistance CFDA 14.321 | U.S. Department of Housing and Urban Development | Housing | $2.0M |
| Division of Ocean Sciences CFDA 47.050 | National Science Foundation | Science & Research | $2.0M |
| DNA Backlog Reduction Program CFDA 16.593 | U.S. Department of Justice | Public Safety | $5.0M |
| Drug Abuse Research Programs CFDA 93.279 | National Institutes of Health | Health | $3.0M |
| Drug Court Discretionary Grant Program CFDA 16.588 | U.S. Department of Justice | Public Safety | $2.0M |
| Early Learning Alignment and Improvement Grants CFDA 84.411 | U.S. Department of Education | Education | $25.0M |
| Early Reading First CFDA 84.348 | U.S. Department of Education | Education | $3.0M |
| Economic Adjustment Assistance CFDA 11.307 | U.S. Department of Commerce | Business & Economic Development | $5.0M |
| Economic Adjustment for Coal Communities CFDA 11.558 | U.S. Department of Commerce | Business & Economic Development | $5.0M |
| Economic Development Assistance Programs CFDA 11.010 | U.S. Department of Commerce | Business & Economic Development | $5.0M |
| Economic Development Technical Assistance Program CFDA 11.302 | U.S. Department of Commerce | Business & Economic Development | $1.0M |
| Economic Development — Technical Assistance CFDA 11.305 | U.S. Department of Commerce | Business & Economic Development | $500K |
| Education for Homeless Children and Youths CFDA 84.196 | U.S. Department of Education | Education | $2.0M |
| Education Research and Development CFDA 84.305 | U.S. Department of Education | Education | $3.0M |
| Educational Exchange — Fulbright Program CFDA 19.020 | U.S. Department of State | Education | $100K |
| Emergency Management Performance Grants (EMPG) CFDA 97.042 | Federal Emergency Management Agency | Public Safety | $5.0M |
| Emergency Solutions Grants CFDA 14.231 | U.S. Department of Housing and Urban Development | Housing | $5.0M |
| Emergency Watershed Protection Program CFDA 10.604 | U.S. Department of Agriculture | Agriculture | $5.0M |
| Employment Service CFDA 17.207 | U.S. Department of Labor | Education | $20.0M |
| Empowering Communities with Alzheimer's CFDA 93.734 | U.S. Department of Health and Human Services | Health | $3.0M |
| Energy Efficiency and Renewable Energy Research CFDA 81.127 | U.S. Department of Energy | Science & Research | $5.0M |
| Energy Storage Technologies CFDA 81.117 | U.S. Department of Energy | Science & Research | $10.0M |
| Engineering Grants CFDA 47.041 | National Science Foundation | Science & Research | $3.0M |
| English Language Acquisition State Grants CFDA 84.365 | U.S. Department of Education | Education | $5.0M |
| Enhanced Mobility of Seniors and Individuals with Disabilities CFDA 20.513 | U.S. Department of Transportation | Transportation | $5.0M |